The TESDA Regional Training Center was formerly known as Regional Manpower Skills Center (RMTC). It was established through Presidential Decree No. 442, as amended in Book 2 Article 5 of the Labor Code of the Philippines, which created the National Manpower and Youth Council (NMYC). The NMYC is tasked to formulate a long-term national manpower plan for optimum allocation: development and utilization of manpower for employment, entrepreneurship, and economic and social growth. In Article 47, the NMYC should create a National Manpower Training Center for the purpose to promote skills development.
The Regional Manpower Training Center - Batangas (RMTC - Batangas) was established for empowering the youth in the field of work. The RMTC - Batangas acquired a lot in 1973 through a deed of donation from the City of Batangas. The building was constructed under the supervision of the Educational Development Projects Implementing Task Force (EDPITAF). It has been operating since 1978. It was during the same year that Welding and Steel Fabrication training was conducted. Nevertheless, the RMTC - Batangas was formally launched and inaugurated on June 27, 1980. Through the years, it was able to offer seven generic trades, namely: Welding and Fabrication, Building Construction, Machine Shop, Electronics, Electrical, Refrigeration and Air-conditioning, and Automotive.
On August 25, 1994, Republic Act 7796 established the Technical Education and Skills Development Authority (TESDA) and changed the name ''Regional Manpower Training Center'' to ''Regional Education and Skills Development Center (RTESDC)''. During the year 2000, it was further renamed Regional Training Center - Batangas (RTC - Batangas) through a memorandum issued by TESDA Director General Edicio G. Dela Torre.
Eventually, in 2007, during the incumbency of Director General Augusto Syjuco, he issued a TESDA Circular renaming Regional Training Center - Batangas to Regional Training Center - CALABARZON (RTC - CALABARZON).